Parturition - Rosengracht - Drainage (Vinyl, LP)

The working lumen 64 of the diagnostic fluid line 33 provides a fluid communication path for the introduction of a diagnostic fluid into the uterine cavity. The pinch clamp 48 see FIG.

This is accomplished by squeezing the pinch clamp 48 into the "locked pinch mode". Opposing projections 49 on the pinch clamp 48 operate on the diagnostic fluid line 33 to occlude the working lumen It should be understood that the structure and operation of such pinch clamps are well known in the art and needn't be describe here in any greater detail. As can be seen, the inflation lumen 66 starts at the proximal end of the inflation fluid line 50 and extends therethrough to the distal end 52 thereof.

The inflation lumen 66 communicates with the interior of balloon 38 via an aperture The inflation lumen 66 of the inflation fluid line 50 provides a communication path for inflating the balloon 38 with either saline or air.

The earlier described inline rotary valve 56 operates to maintain the balloon in the inflated state after inflation by the inflation syringe In operation, the balloon 38 is inflated by pushing the plunger 60 into the body 62 of the inflation syringe 58 see FIG.

Once the balloon 38 is inflated, the inline rotary valve 56 is rotated into the "closed position" which prevents communication between the inflation syringe 58 and the inflation lumen When it is desirable to deflate the balloon 38, the inline rotary valve is rotated into the "open position" which reestablishes communication between the inflation syringe 58 and the inflation lumen To deflate the balloon 38, the plunger 60 is pulled toward the proximal end of the body 62 of the inflation syringe All the components of the catheter 30 of the present invention are made from conventional materials such as nylon, polyethylene, or a composite.

The balloon 38 of the present invention can be placed in the cervix 22 to occlude the cervical canal 24 as shown in FIG. This is made possible by the novel construction of the balloon 38 which enables it to be progressively transformed from an ellipsoidal shape as shown in FIG.

This is made possible by fabricating the balloon 38 from a polyurethane material and attaching it to the body 32 of the catheter 30 so that the longitudinal axis L of the balloon is longer than the transverse axis T of the balloon upon initial inflation. This produces a balloon that is substantially elliptical in shape shown in FIG. Accordingly, the ellipsoidal shape of the balloon 38 matches the natural shape of the spindle 26 of the cervical canal The progressive inflation characteristics and the elliptical shape of the balloon 38 of the catheter of the present invention enable it to be used to occlude the cervical canal with minimal pain, compared to conventional prior art spherical-shaped latex intracervical balloons.

Further, the balloon 38 can be progressively inflated to a substantially spherical shape with additional inflation pressure. More specifically, additional inflation pressure increases only the transverse axis T of the balloon 38 which results in a balloon with a substantially spherical shape. Patent Application No. The balloon of Piraka is filled with a liquid medium, such as water or saline solution, by means of a catheter inserted through a valve in the balloon.

A fill system, a control system, and a pressure relief valve are each employed for maintaining a constant solution pressure in the balloon.

However, the pressure of the liquid medium is difficult to control and manage, especially when the balloon is only partially filled with such liquid medium. Further, weight of the liquid medium imposes additional pressure on the lower portion of the vaginal or uterine wall, which intensifies the discomfort of the patient during the procedure and may even result in injury of the soft tissues on the vaginal or uterine wall.

It is therefore an object of the present invention to provide a balloon catheter for controlling post-partum hemorrhage, with enhanced pressure control and reduced weight.

The present invention in one aspect relates to a dual balloon catheter that is inflatable by a gaseous inflation medium. Specifically, such balloon catheter comprises a first balloon, a second balloon that encompasses such first balloon, and a catheter having an inflation lumen and a deflation lumen that are separated from each other. The first balloon is in fluid communication with the inflation lumen of the catheter, and the second balloon is in fluid communication with the deflation lumen.

After such dual balloon catheter is inserted into a body cavity, a biologically and physiologically compatible gaseous inflation medium, which includes but is not limited to, air, O 2 , N 2 , Ar 2 , CO 2 , etc. The inflated first balloon applies a substantially even pressure along an inner surface of such body cavity, therefore reducing or eliminating bleeding alone such inner surface.

The second balloon is not inflated but conforms to the contour of the first balloon. In the event that any gaseous inflation medium escapes from the first balloon, due to either leakage or rapture, such second balloon functions to confine the escaped gaseous medium and discharge it through the deflation lumen.

Therefore, the risk of gas embolism, which is caused by the entry of gas bubbles into the blood stream through hemorrhage sites and which may result in severe injury or even death, is significantly reduced by using the dual balloon catheter of the present invention.

Moreover, the dual balloon catheter of the present invention, as inflated by a gaseous inflation medium, provides easy, accurate, and quick control of the pressure that is applied to the inner surface of a body cavity thereby. Further, the weight of the gas-inflated balloon of the present invention is significantly less than that of the liquid-inflated balloon disclosed by Piraka in U. Such dual balloon catheter can be inserted into a body cavity, such as uterine cavity, vaginal cavity, oral cavity, nasal cavity, cranial cavity, vertebral cavity, thoracic cavity, mediastinum, abdominal cavity, etc.

Alternatively, such dual balloon catheter can be used for dilating blood vessels to treat certain types of obstructions or occlusions therein. The contour of the balloons used depends on the specific shape of the body cavity to which the dual balloon catheter is inserted.

For instance, when such dual balloon catheter is inserted into a uterine cavity, the first and second balloons are characterized by a heart-shaped contour that conforms to the inner surface of the uterine cavity; when such dual balloon catheter is inserted into a blood vessel, the first and second balloons are characterized by an elongated, tubular contour that conforms to the inner surface of the blood vessel.

Conformance of the contour of the balloons with the interior shape of the body cavity enables such balloons to fit evenly and tightly against the inner surface of the body cavity, thereby providing pressure against all associated bleeding sites.

Another aspect of the present invention relates to a dual balloon catheter that is inflatable by a gaseous medium and a liquid medium. Anti-inflammatory effects of new catechin derivatives in a hapten-induced mouse contact dermatitis model.

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Fast super-resolution with iterative-guided back projection for 3D MR images. Post-partum hemorrhage is most commonly caused by uterine atony whereby the uterus fails to contract normally after the delivery of a baby.

This condition occurs in about 5 percent of deliveries. Hemorrhage continues to be one of the major causes of maternal deaths generally, with obstetrical hemorrhage being the third leading cause of maternal death by hemorrhage in the United States. Worldwide, maternal hemorrhage qualifies as the leading cause of maternal death.

Techniques for managing obstetrical hemorrhage may be medical, mechanical, or surgical. Hysterectomy, while an effective surgical procedure for treating this condition, bears severe consequences, in particular for young women who have not completed childbearing. One of the mechanical procedures often used for managing obstetrical hemorrhage involves packing the uterus with heavy gauze. This procedure remains controversial because of a high failure rate, and is considered a waste of time by some medical practitioners.

The high failure rate is attributable to the inherent difficulty in packing the uterus properly so that there is an even distribution of pressure along the entire inner surface of the organ. Accordingly, a more effective procedure is needed to address post-partum hemorrhage and bleeding.

Ideally, the procedure should present minimal long-term health consequences to the patient, be quickly and easily accomplished, be easily learned and require no specialized instrumentation. Patent Application Publication No. The balloon of Piraka is filled with a liquid medium, such as water or saline solution, by means of a catheter inserted through a valve in the balloon. A fill system, a control system, and a pressure relief valve are each employed for maintaining a constant solution pressure in the balloon.

However, the pressure of the liquid medium is difficult to control and manage, especially when the balloon is only partially filled with such liquid medium. Further, weight of the liquid medium imposes additional pressure on the lower portion of the vaginal or uterine wall, which intensifies the discomfort of the patient during the procedure and may even result in injury of the soft tissues on the vaginal or uterine wall.

It is therefore an object of the present invention to provide a balloon catheter for controlling post-partum hemorrhage, with enhanced pressure control and reduced weight. The present invention in one aspect relates to a dual balloon catheter that is inflatable by a gaseous inflation medium. Specifically, such balloon catheter comprises a first balloon, a second balloon that encompasses such first balloon, and a catheter having an inflation lumen and a deflation lumen that are separated from each other.

The first balloon is in fluid communication with the inflation lumen of the catheter, and the second balloon is in fluid communication with the deflation lumen. After such dual balloon catheter is inserted into a body cavity, a biologically and physiologically compatible gaseous inflation medium, which includes but is not limited to, air, O 2 , N 2 , Ar 2 , CO 2 , etc. The inflated first balloon applies a substantially even pressure along an inner surface of such body cavity, therefore reducing or eliminating bleeding alone such inner surface.

The second balloon is not inflated but conforms to the contour of the first balloon. Simple Solution My White Bicycle Love Hurts Open Up Woman Abscession - Grave Offerings Where Sleeping Gods Dwell Gargoyle In My Coffin Cabin 13 Blowtorch Blues Freshly Dug Graves Plague Bearer The Ruiner Engorged With Gore Downfall Part 1. Lifted - Healing of the Nation Let Go Lost Control Right Perfect Day Getaway Praise feat. Realize Faces Jump The Gun World On Fire See The Light Future Changes - Home Again Home Again A2.

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Cited By. This article is cited by 46 publications. Journal of Medicinal Chemistry , 61 8 , Journal of Medicinal Chemistry , 60 17 , Discovery of 2-[[2-Ethyl[4-[2- 3-hydroxyazetidinyl oxoethyl]piperazinyl]methylimidazo[1,2-a]pyridinyl]methylamino] 4-fluorophenyl thiazolecarbonitrile GLPG , a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis.

Journal of Medicinal Chemistry , 60 9 , Parrill, Truc Chi T. Pham, Daniel L. Baker, Gabor J. Tigyi, and Duane D. Journal of Medicinal Chemistry , 60 4 , Young, Emma L. Pritchard, Anastassis Perrakis, Simon J. Macdonald, Craig Jamieson, and Allan J. Journal of Medicinal Chemistry , 60 2 , Budd, Simon J. Journal of Medicinal Chemistry , 59 12 , Norman, Shanshan Deng, Sayo O.

Parrill, Wei Li, Duane D. Miller, Gabor J. Molecular modelling guided design, synthesis and QSAR analysis of new small molecule non-lipid autotaxin inhibitors. Bioorganic Chemistry , , Synthesis of novel 2-pyrrolidinone and pyrrolidine derivatives and study of their inhibitory activity against autotaxin enzyme.

Phosphinoyl radical-initiated vicinal hydroxy-phosphorylation of alkenes. Tetrahedron , 75 47 , Oxidized Lipids in Persistent Pain States. Benzoxaboroles—Novel Autotaxin Inhibitors. Molecules , 24 19 , Anti-Cancer Agents in Medicinal Chemistry , 19 2 , Matralis, Antreas Afantitis, Vassilis Aidinis.

Development and therapeutic potential of autotaxin small molecule inhibitors: From bench to advanced clinical trials. Medicinal Research Reviews , 39 3 , Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency.

Journal of Biological Chemistry , 37 , Autotaxin inhibitors: a patent review Expert Opinion on Therapeutic Patents , 27 7 , A rhodium III -based inhibitor of autotaxin with antiproliferative activity. Ma, Angelina M. Santini, Adam J. Stein, Dave Lonergan, Christopher D. Hutchinson, Jilly F. Journal of Pharmacology and Experimental Therapeutics , 1 , Ragle, Dilip J. Palanisamy, Margaux J. Joe, Rachel S. Stein, Derek D. Norman, Gabor Tigyi, Daniel L.

Baker, Abby L. Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition. Molecules , 21 9 , Phosphono- and Phosphinolactones in the Life Sciences. Supuran, Eli Breuer. Carbamoylphosphonates inhibit autotaxin and metastasis formation in vivo.

Journal of Enzyme Inhibition and Medicinal Chemistry , 30 5 , Murph, Guowei W. Jiang, Molly K. Altman, Wei Jia, Duy T. Nguyen, Jada M. Fambrough, William J. Hardman, Ha T. Nguyen, Sterling K. Tran, Ali A. Vinyl sulfone analogs of lysophosphatidylcholine irreversibly inhibit autotaxin and prevent angiogenesis in melanoma.

Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer. Endocrine-Related Cancer , 22 4 , Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer. Progress in Lipid Research , 58 , The status of the lysophosphatidic acid receptor type 1 LPA 1 R. MedChemComm , 6 1 , Benesch, Yi M. Ko, Todd P. McMullen, David N. Autotaxin in the crosshairs: Taking aim at cancer and other inflammatory conditions. FEBS Letters , 16 , Scott, Thomas P.

Mathews, Pavlina T. Ivanova, Craig W. Lindsley, H. Alex Brown. Chemical modulation of glycerolipid signaling and metabolic pathways. Medicinal Research Reviews , 34 4 , Zhao, Bernard P. Curtis, Todd P. Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice. Journal of Ocular Pharmacology and Therapeutics , 30 , Norman, Ryoko Tsukahara, Jason R. Miller, Abby L. Baker, Robert Bittman, Gabor Tigyi. Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif.

FEBS Journal , 4 , Smyth, Andrew J. Tumor Microenvironment as Target in Cancer Therapy. Prestwich, Charles A. Development of lysophosphatidic acid pathway modulators as therapies for fibrosis. Future Medicinal Chemistry , 5 16 , Miller, R. Parrill, Daniel L. Molecular Pharmacology , 84 3 , Autotaxin inhibitors: a patent review. Expert Opinion on Therapeutic Patents , 23 9 , Prestwich, Vassilis Aidinis,.

Molecular Biology of Atherosclerosis. Physiological Reviews , 93 3 , Archiv der Pharmazie , 2 , Autotaxin and lysophosphatidic acid signalling in lung pathophysiology.

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8 thoughts on “Parturition - Rosengracht - Drainage (Vinyl, LP)

  1. Jun 02,  · View credits, reviews, tracks and shop for the Vinyl release of Drainage on Discogs. Label: Not On Label (Rosengracht) - ME • Format: Vinyl LP • 4/5(3).
  2. LP Proscriptor The Venus Bellona Cruel Moon International 13 Red vinyl LP Rosengracht Drainage Rose 17 7″ SalikaPalikau + King Lear’s Convulsions Vitreous pilgrims border HauRuck 5 CD Sally Doherty and the Sumacs Black Is The Colour World Serpent
  3. A dual balloon catheter apparatus for controlling postpartum hemorrhage in uterine or vaginal cavities or hemorrhage in other body cavities, comprising: (1) a catheter having an inflation lumen and a deflation lumen; (2) a first inflatable balloon in fluid communication with the inflation lumen; and (3) a second inflatable balloon encompassing the first balloon and in fluid communication with Cited by:
  4. A configurable percutaneous endoscopic gastrostomy tube includes a shaft having a distal end and a proximal end. The shaft defines a lumen therethrough for passage of a feeding solution or medicine. An expandable retainer is located on the shaft, the retainer having a deployed position and an insertion position. The tube includes a releasable lock for maintaining the expandable retainer in its Cited by:
  5. USB2 US10/, USA USB2 US B2 US B2 US B2 US A US A US A US B2 US B2 US B2 Authority US United States Prior art keywords balloon lumen inflation catheter gaseous Prior art date Legal status (The legal status is an assumption and is not a legal grotbersjosthoddfessilk.idderremicawargazanpiekomsymplead.co by:
  6. A catheter for non-surgical entry into the cervical canal or the uterus, comprising an elongated tubular catheter body. An inflatable balloon manufactured from a polyurethane material is disposed proximal to the distal end of the catheter body. The polyurethane inflatable balloon can be progressively inflated into an elliptical shape which enables the balloon to be used within the cervical grotbersjosthoddfessilk.idderremicawargazanpiekomsymplead.cog: Rosengracht.
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